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L-asparaginase--a reassessment
11st Clinic of Internal Medicine, Medical Faculty, Palacký University, Olomouc, Czechoslovakia.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae
|January 1, 1991
Abstract:
The authors review some historical data connected with the discovery of the enzyme l-asparaginase and then summarize the basic informations concerning the mechanism of action, clinical application, toxicity and future prospectives of this substance. From the clinical viewpoint, a broader use of l-asparaginase prepared from Erwinia carotovora instead of Escherichia coli seems to be warranted.