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Related Concept Videos

Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...

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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

Self-immolative polymers.

Amit Sagi1, Roy Weinstain, Naama Karton

  • 1School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv 69978 Israel.

Journal of the American Chemical Society
|April 2, 2008
PubMed
Summary
This summary is machine-generated.

Researchers created a novel smart polymer that breaks down sequentially when triggered. This self-immolative polymer amplifies signals, enabling highly sensitive molecular sensors for detecting various biological and chemical activities.

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Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
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Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Smart polymers respond to external stimuli.
  • Sequential disassembly of polymers is a developing field.
  • Molecular sensors require high sensitivity and signal amplification.

Purpose of the Study:

  • To develop a novel smart polymer capable of sequential disassembly.
  • To create a self-immolative polymer system for signal amplification.
  • To demonstrate the utility of these polymers in highly sensitive molecular sensors.

Main Methods:

  • Synthesized a polyurethane-based smart polymer.
  • Utilized domino-like 1,6-elimination and decarboxylation reactions for disassembly.
  • Confirmed head-to-tail disassembly and signal amplification using fluorogenic molecules.

Main Results:

  • Successfully synthesized a smart polymer that undergoes sequential, head-to-tail disassembly.
  • Demonstrated amplification of a single cleavage event into multiple releases.
  • Achieved a large signal-to-noise ratio in sensor applications.

Conclusions:

  • The developed smart polymer enables controlled, sequential disassembly.
  • This self-immolative polymer system offers significant signal amplification.
  • The smart polymers are promising for developing highly sensitive molecular sensors for diverse applications.