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[Pneumonitis associated to methotrexate].

D Sáenz Abad¹, F J Ruiz-Ruiz, S Monón Ballarín

¹Servicios de Urgencias, Hospital Clínico Universitario Lozano Blesa, Zaragoza. danielsaenzabad@hotmail.com

Anales De Medicina Interna (Madrid, Spain : 1984)

|April 2, 2008

Summary

This summary is machine-generated.

Methotrexate (MTX) can cause lung damage, specifically acute interstitial pneumonitis. Early detection and treatment, including MTX withdrawal and corticosteroids, led to full recovery in a patient with autoimmune thrombocytopenia.

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Area of Science:

Pulmonology
Rheumatology
Pharmacology

Background:

Methotrexate (MTX) is a folic acid antagonist used for its anti-inflammatory properties.
Acute interstitial pneumonitis is a known pulmonary complication of MTX therapy.

Observation:

A 56-year-old woman with autoimmune thrombocytopenia developed subacute cough, dyspnea, fever, and malaise.
Chest imaging revealed bilateral interstitial and alveolar infiltrates.
Infectious causes were excluded.

Findings:

Methotrexate-induced pneumonitis was diagnosed.
Discontinuation of MTX and initiation of methylprednisolone treatment resulted in progressive symptom improvement.
Complete resolution of clinical and radiological findings occurred within eight weeks.

Implications:

This case highlights the importance of recognizing MTX-induced pneumonitis in patients on MTX therapy.
Prompt diagnosis and management, including drug withdrawal and corticosteroid use, are crucial for favorable outcomes.
Awareness of this adverse effect is essential for clinicians managing patients with autoimmune diseases or receiving MTX for other indications.