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Related Experiment Video

Updated: Feb 6, 2026

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
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Neuroprotectants in stroke therapy.

K Jeyaseelan1, K Y Lim, A Armugam

  • 1Department of Biochemistry, National University of Singapore, Yong Loo Lin School of Medicine, Singapore. bchjeya@nus.edu.sg

Expert Opinion on Pharmacotherapy
|April 2, 2008
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Summary
This summary is machine-generated.

Despite past failures in clinical trials for stroke neuroprotection, this review highlights promising candidates, including novel non-coding small RNAs (riboregulators), for further investigation to reverse stroke effects.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biotechnology

Background:

  • Clinical trials for stroke neuroprotection have yielded no success over the last decade.
  • Identifying effective neuroprotectants to reverse stroke effects remains a significant challenge for medical professionals and researchers.

Purpose of the Study:

  • To review the current landscape of neuroprotective agents for stroke.
  • To identify neuroprotective compounds with potential for further preclinical or clinical examination.
  • To introduce novel therapeutic leads, such as riboregulators, for stroke treatment.

Main Methods:

  • Comprehensive review of recent scientific findings and clinical trial outcomes.
  • Analysis of neuroprotective agents that showed promise in preclinical studies but failed in clinical trials.
  • Inclusion of emerging therapeutic strategies, including non-coding small RNAs.

Main Results:

  • Numerous neuroprotective agents effective in preclinical settings have proven ineffective in human clinical trials.
  • Certain previously investigated neuroprotectants warrant re-examination due to potential therapeutic value.
  • Non-coding small RNAs (riboregulators) are presented as a novel class of therapeutic agents for stroke.

Conclusions:

  • The transition from preclinical efficacy to clinical success for stroke neuroprotectants remains problematic.
  • Re-evaluation of some neuroprotective agents may yield future therapeutic breakthroughs.
  • Non-coding small RNAs (riboregulators) represent a promising avenue for developing new stroke therapies.