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Updated: Jul 6, 2026
08:49
Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals
Published on: February 14, 2019
Application of carbohydrate array technology to antigen discovery and vaccine development
Oyindasola Oyelaran1, Jeffrey C Gildersleeve
1National Cancer Institute, Laboratory of Medicinal Chemistry, Center for Cancer Research, NIH, 376 Boyles Street, Building 376, Room 109, Frederick, MD 21702, USA. oyelarano@ncifcrf.gov
Expert Review of Vaccines
|April 2, 2008
Summary
Carbohydrate arrays enable rapid, high-throughput screening of carbohydrate-protein interactions for vaccine development. This technology accelerates the discovery of carbohydrate antigens and evaluation of immune responses to vaccine candidates.
Area of Science:
- Glycoscience
- Immunology
- Biotechnology
Background:
- Carbohydrate arrays are an emerging technology for analyzing molecular interactions.
- They immobilize diverse carbohydrate structures on a solid support for efficient analysis.
- This platform facilitates the study of carbohydrate-protein, carbohydrate-cell, and carbohydrate-virus interactions.
Purpose of the Study:
- To highlight the application of carbohydrate arrays in vaccine development.
- To discuss their utility in discovering and characterizing carbohydrate antigens.
- To explain their role in assessing immune responses and identifying key reagents for vaccines.
Main Methods:
- Utilizing carbohydrate arrays for high-throughput screening.
- Characterizing carbohydrate antigens using array-based assays.
- Evaluating immune responses to vaccine candidates via array analysis.
- Identifying and characterizing essential reagents for vaccine formulation.
Main Results:
- Carbohydrate arrays enable efficient discovery and characterization of carbohydrate antigens.
- They are effective in evaluating immune responses to potential vaccine candidates.
- The technology aids in identifying and characterizing crucial reagents for vaccine development.
Conclusions:
- Carbohydrate array technology is a powerful tool for advancing vaccine development.
- Despite being in early stages, it shows significant potential for accelerating the vaccine creation process.
- This platform offers a high-throughput, low-material approach to key aspects of vaccine research.
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