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Published on: July 18, 2014
Survival and health in liveborn infants with transposition of great arteries--a population-based study
Ester Garne1, Maria A Loane, Vera Nelen
1Paediatric Department, Kolding Hospital, Kolding, Denmark. egarne@health.sdu.dk
Objective:
To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).
Design:
Population-based data from 7 European registries of congenital malformations (EUROCAT).
Results:
Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.
Conclusions:
In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.
