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Renal calculi complicating short-term furosemide therapy after congenital heart surgery

Sulafa K M Ali1

  • 1Sudan Heart Center, Khartoum, Sudan. sulafakhalid2000@yahoo.com

Congenital Heart Disease
|April 2, 2008
PubMed

Insights

Short-term Furosemide use in children with congenital heart disease can lead to renal calculi (kidney stones). Close monitoring of urine is recommended to detect this complication early.

Area of Science:

  • Pediatric Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Renal calcification is a recognized adverse effect of Furosemide treatment.
  • Congenital heart disease often requires interventions necessitating medications like Furosemide.

Observation:

  • Three pediatric patients developed renal calculi after 4 weeks of Furosemide therapy (1-2 mg/kg/day).
  • These infants had undergone successful repair or palliation for congenital heart disease.
  • Diagnosis was renal calculi, specifically excluding nephrocalcinosis.

Findings:

  • Renal ultrasound confirmed renal calculi in all three patients.
  • No evidence of nephrocalcinosis was observed.
  • Hematuria, a presenting symptom, resolved within 3-4 months post-treatment.

Implications:

  • Short-term Furosemide administration can cause renal calculi in pediatric patients post-cardiac surgery.
  • Routine urine analysis and monitoring of urine calcium/creatinine ratio are crucial for early detection.
  • This highlights the importance of vigilant monitoring for Furosemide-induced renal complications in vulnerable pediatric populations.
Abstract

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