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Multimeric alpha-MSH has increased efficacy to activate the melanocortin MC4 receptor

Birgitte Tiesjema1, Myrte Merkestein, Keith M Garner

  • 1Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands.

European Journal of Pharmacology
|April 2, 2008
PubMed
Summary

Multimeric alpha-Melanocyte stimulating hormone (alpha-MSH) constructs show enhanced binding and activation of the melanocortin MC4 receptor. Increasing the number of alpha-MSH subunits significantly improved receptor activation in vitro.

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