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Updated: Jul 6, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

BNP or NTproBNP? A clinician's perspective.

Johannes Steiner¹, Maya Guglin

¹University of South Florida, United States.

International Journal of Cardiology

|April 2, 2008

Summary

B-type natriuretic peptide (BNP) and amino terminal pro-brain natriuretic peptide (NTproBNP) are key cardiac dysfunction markers. While often interchangeable, NTproBNP may be better for diagnosing mild heart failure.

Area of Science:

Cardiology
Biomarkers
Heart Failure Diagnostics

Background:

B-type natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NTproBNP) are established biomarkers for cardiac dysfunction.
Existing literature often focuses on individual peptides, hindering direct comparison.
Concomitant diseases can influence natriuretic peptide levels, complicating interpretation.

Purpose of the Study:

To review and compare studies directly evaluating BNP and NTproBNP.
To analyze peptide performance in chronic and acute heart failure (HF) and coronary artery disease.
To provide guidance on the practical application of these biomarkers.

Main Methods:

Systematic review of comparative studies on BNP and NTproBNP.

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Last Updated: Jul 6, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Analysis of data from patients with heart failure and coronary artery disease.

Consideration of confounding factors affecting peptide levels.

Main Results:

BNP and NTproBNP are largely interchangeable for clinical use in heart failure.
NTproBNP demonstrates potential advantages in diagnosing mild heart failure or asymptomatic left ventricular dysfunction.
Interpretation requires consideration of influencing comorbidities.

Conclusions:

BNP and NTproBNP serve as valuable, interchangeable markers for cardiac dysfunction.
NTproBNP may offer superior sensitivity for detecting early-stage or subclinical cardiac issues.
Clinical choice between BNP and NTproBNP can be based on availability and local protocols.