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Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study.

Deependra Singh1, Swarnlata Saraf, Vinod Kumar Dixit

  • 1Institute of Pharmacy, Pt. Ravishankar Shukla University, CG-492010, India.

Biological & Pharmaceutical Bulletin
|April 2, 2008
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Summary

This study optimized gentamicin-loaded Eudragit RS100 microspheres for controlled delivery. Formulation parameters like sodium chloride and glycerol significantly influenced entrapment, yield, and size, achieving sustained 24-hour drug release.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Gentamicin is a crucial antibiotic requiring optimized delivery methods.
  • Eudragit RS100 offers potential for controlled-release formulations.
  • Microsphere technology enables sustained drug release and improved therapeutic outcomes.

Purpose of the Study:

  • To develop and characterize gentamicin-loaded Eudragit RS100 microspheres.
  • To investigate the impact of formulation variables on microsphere properties.
  • To achieve sustained in vitro release of gentamicin.

Main Methods:

  • Modified double emulsion method for microsphere preparation.
  • 3(2) full factorial design to study glycerol and sodium chloride effects.
  • In vitro drug release studies and particle size analysis.

Main Results:

  • Sodium chloride significantly affected entrapment efficiency and yield.
  • Glycerol concentration impacted microsphere size (33.24-60.43 µm).
  • Optimized formulation showed sustained release for 24 hours, following Higuchi kinetics, with intact drug bioactivity.

Conclusions:

  • Formulation parameters can be optimized for gentamicin-loaded Eudragit RS100 microspheres.
  • This approach facilitates controlled delivery with desired characteristics.
  • The developed microspheres offer potential for effective gentamicin therapy.