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Hepatocellular carcinoma with direct invasion to the stomach causing gastrointestinal hemorrhage

Ken Kimura1, Hideaki Miura, Satoshi Saito

  • 1Division of Internal Medicine, Social Insurance Central General Hospital, Tokyo, Japan. kenkimura@juno.ocn.ne.jp

Internal Medicine (Tokyo, Japan)
|April 2, 2008
PubMed

Insights

Hepatocellular carcinoma (HCC) recurred and invaded the stomach, causing gastrointestinal bleeding despite multiple transcatheter arterial embolizations (TAE). The patient ultimately succumbed to liver failure.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) is a common primary liver cancer.
  • Transcatheter arterial embolization (TAE) is a treatment option for unresectable HCC.
  • Recurrence and complications remain significant challenges in HCC management.

Observation:

  • A 54-year-old male with hepatitis B virus-related HCC underwent four TAE procedures.
  • Recurrent HCC demonstrated extrahepatic growth, invading the gastric wall.
  • The patient presented with anemia due to gastrointestinal hemorrhage from tumor invasion.

Findings:

  • Computed tomography and endoscopy confirmed direct HCC invasion of the stomach.
  • Endoscopic hemostasis provided temporary control of gastrointestinal bleeding.
  • Despite interventions, the patient died from progressive hepatic failure.

Implications:

  • This case highlights the potential for aggressive HCC recurrence and extrahepatic spread.
  • Direct tumor invasion of adjacent organs can lead to severe complications like hemorrhage.
  • Advanced hepatic failure remains a critical factor influencing patient outcomes in complex HCC cases.

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