Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Control of Respiration01:23

Physiological Control of Respiration

Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Respiration and Gaseous Exchange01:20

Respiration and Gaseous Exchange

The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
Gas Exchange and Transport01:20

Gas Exchange and Transport

Gas exchange, the intake of molecular oxygen (O2) from the environment and the outflow of carbon dioxide (CO2) into the environment, is necessary for cellular function. Gas exchange during respiration occurs largely via the movement of gas molecules along pressure gradients. Gas travels from areas of higher partial pressure to areas of lower partial pressure. In mammals, gas exchange occurs in the alveoli of the lungs, which are adjacent to capillaries and share a membrane with them.
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effects of Nitrate and Nitrite Supplementation on Mitochondrial Respiration in Permeabilized Muscle Fibres in Young Healthy Adults.

Nitric oxide : biology and chemistry·2026
Same author

Rates of maximal blood lactate accumulation in the extreme intensity exercise domain: implications for training prescription.

European journal of applied physiology·2026
Same author

Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.

Comprehensive Physiology·2026
Same author

Greatest of All Time: Development of a Ranking System to Determine the Most Successful Olympic and World Championship Runners Since 1896.

Sports medicine (Auckland, N.Z.)·2026
Same author

35 Years of Joyner's Endurance Performance Model: Assessing the Contribution of Physiological Determinants of Performance Proxies in 888 Individuals from Recreational to World Class.

Sports medicine (Auckland, N.Z.)·2026
Same author

New Trends in Sport Science-Observations From the 30th Annual Congress of the European College of Sport Science in Rimini.

European journal of sport science·2026

Related Experiment Video

Updated: Jul 6, 2026

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
09:04

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy

Published on: February 20, 2018

Control of oxygen uptake during exercise.

David C Poole1, Thomas J Barstow, Paul McDonough

  • 1Department of Kinesiology, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506-5802, USA. poole@vet.ksu.edu

Medicine and Science in Sports and Exercise
|April 2, 2008
PubMed
Summary

Human oxygen uptake (V O2) kinetics during exercise transitions are dynamic, not steady. Muscle fiber type and O2 delivery influence these responses, impacting exercise capacity and disease states.

More Related Videos

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Using Near-Infrared Spectroscopy Wearable Devices to Identify Central Versus Peripheral Limitations During Exercise
09:33

Using Near-Infrared Spectroscopy Wearable Devices to Identify Central Versus Peripheral Limitations During Exercise

Published on: December 19, 2024

Related Experiment Videos

Last Updated: Jul 6, 2026

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
09:04

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy

Published on: February 20, 2018

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Using Near-Infrared Spectroscopy Wearable Devices to Identify Central Versus Peripheral Limitations During Exercise
09:33

Using Near-Infrared Spectroscopy Wearable Devices to Identify Central Versus Peripheral Limitations During Exercise

Published on: December 19, 2024

Area of Science:

  • Physiology
  • Exercise Physiology
  • Metabolic Control

Background:

  • Humans rarely maintain steady metabolic states, constantly transitioning between different oxygen consumption rates (V O2).
  • Understanding the dynamic changes in V O2 (V O2 kinetics) during transitions, like exercise onset, is crucial for metabolic control insights.
  • Established models explain V O2 kinetics' work rate dependence and responses to environmental changes and diseases.

Purpose of the Study:

  • To review the current understanding of V O2 kinetics control.
  • To integrate novel approaches and technologies with existing concepts.
  • To assess the role of oxygen (O2) supply in V O2 kinetics under various conditions.

Main Methods:

  • Review of existing literature and established concepts.
  • Integration of novel approaches and technologies.
  • Analysis of O2 supply and V O2 relationships at the capillary-myocyte interface.

Main Results:

  • Challenges the extrapolation of capillary blood flow from arterial measurements.
  • Highlights complexities in O2 supply/flux across the capillary-myocyte interface.
  • Demonstrates marked dependence on muscle fiber type, with lower O2 in fast-twitch fibers.

Conclusions:

  • Fiber type recruitment may explain slowed V O2 kinetics at higher work rates.
  • Altered fiber type recruitment could contribute to V O2 kinetics impairments in heart failure and diabetes.
  • O2 levels in microcirculation and muscle O2 sensitivity are key factors in V O2 kinetics.