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Related Experiment Video

Updated: Jul 6, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Multicenter, randomized, controlled trials evaluating mortality in intensive care: doomed to fail?

Gustavo A Ospina-Tascón1, Gustavo Luiz Büchele, Jean-Louis Vincent

  • 1Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium.

Critical Care Medicine
|April 2, 2008
PubMed
Summary

Few randomized controlled trials in intensive care units show improved survival. Methodological quality may impact results, suggesting a need for diverse evidence and outcomes beyond mortality for critically ill patients.

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Last Updated: Jul 6, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Area of Science:

  • Critical Care Medicine
  • Clinical Trials Research
  • Evidence-Based Medicine

Background:

  • Mortality is a key outcome in intensive care.
  • Multicenter randomized controlled trials (RCTs) are crucial for evaluating interventions.

Purpose of the Study:

  • To quantify published multicenter RCTs in adult intensive care units (ICUs) using mortality as a primary outcome.
  • To assess the methodological quality of these trials.

Main Methods:

  • Conducted a sensitive search for RCTs in Cochrane Central Register and MedLine.
  • Included adult, multicenter RCTs in ICUs with >50 patients and mortality as a primary outcome.

Main Results:

  • Seventy-two RCTs were identified.
  • Ten trials showed a beneficial effect on mortality, seven showed a detrimental effect, and 55 showed no significant effect.

Conclusions:

  • Few ICU RCTs demonstrate a survival benefit from interventions.
  • Methodological limitations may obscure positive findings.
  • Consider alternative endpoints and evidence beyond mortality for critically ill patients.