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Related Experiment Video

Updated: Jul 6, 2026

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps

Published on: August 2, 2024

Shift work, hCLOCK T3111C polymorphism, and endometriosis risk.

Jennifer L Marino¹, Victoria L Holt, Chu Chen

¹Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA. jmarino@fhcrc.org

Epidemiology (Cambridge, Mass.)

|April 2, 2008

Summary

Night shift work may increase endometriosis risk. Women working nights had a higher chance of developing this condition, especially those working more than half their shifts at night.

Related Experiment Videos

Last Updated: Jul 6, 2026

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps

Published on: August 2, 2024

Area of Science:

Reproductive health
Epidemiology
Chronobiology

Background:

Endometriosis affects 5-10% of reproductive-age women and is linked to high estrogen levels.
Night shift work is associated with menstrual disruption and increased risk of estrogen-influenced diseases like breast cancer.

Purpose of the Study:

To investigate the association between night shift work and endometriosis risk.
To explore the potential role of T3111C hCLOCK polymorphism in this association.

Main Methods:

Population-based case-control study involving 235 endometriosis cases and 545 controls.
Participants reported on night shift work history from age 18.
T3111C hCLOCK genotypes were analyzed in a subset of participants.

Main Results:

Any night shift work showed a 50% increased risk of endometriosis (OR=1.48).
Working more than half of shifts at night nearly doubled the risk (OR=1.98).
Disrupted sleep patterns further increased disease risk; T3111C hCLOCK polymorphism was not associated with endometriosis or modifying the effect of shift work.

Conclusions:

Findings suggest certain aspects of night shift work may contribute to endometriosis development.
Further research is warranted to elucidate the mechanisms linking shift work and endometriosis.