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[Mental and behavioral disorders in idiopathic focal epileptiform spikes]

L R Zenkov, P A Konstantinov, I Iu Shiriaeva

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |April 2, 2008
    PubMed

    Insights

    Idiopathic focal epileptiform spikes in children, including centro-temporal (rolandic) and occipital spikes, are linked to various neurodevelopmental and behavioral disorders. Treatment targeting EEG-controlled inhibition shows promise for improving school adaptation.

    Area of Science:

    • Pediatric Neurology
    • Neurophysiology

    Context:

    • Investigates "benign epileptiform spikes" in children without seizures.
    • Studies 200 children aged 3-17 with mental, behavioral, and neuropsychological disorders.

    Purpose:

    • To explore clinical correlates of centro-temporal (rolandic) and occipital spikes.
    • To establish the relationship between spike localization and specific disorders.
    • To propose optimal diagnostic and therapeutic approaches.

    Summary:

    • Centro-temporal spikes (left hemisphere) correlate with speech disorders in older children.
    • Occipital spikes (right hemisphere) correlate with non-verbal/neuropsychological issues in younger children.
    • Both spike types are associated with a spectrum of behavioral and cognitive impairments.

    Impact:

    • Suggests "idiopathic focal epileptiform spikes in children" as a new classification.
    • Recommends comprehensive evaluation including EEG, neuropsychological, and pediatric assessments.
    • Highlights EEG-controlled inhibition as a treatment to improve school outcomes, with valproic acid, lamotrigine, and levetiracetam as potential drugs.

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