[Adenylat-kinase-Systeme, ein Beitrag zum manisch-depressiven Kranksein (MDK)]

Adenylate-kinase (AK) interacts in the balance of phosphate acceptors and donators. With respect to the polymorphism of enzyms of erythrocytes there can be assumed a system of two co-dominate allels determined by the genotype of AK 1 and AK 2 with the phenotypes of AK 1-1, AK 2-1 and AK 2-2. The distribution of AK within 108 cases of MDS and 90 controls was examined. AK 2-1 was found in about 30% of bipolar MDS, but in no case of unipolar MDS or controls. The possible relations were discussed demonstrating a synopsis of the pathogenesis of MDS.