[Effect of molsidomine infusion on thrombocyte function in acute myocardial infarct]

In 10 patients with acute myocardial infarction i.v. molsidomine was given over 48 h and a number of platelet functions was evaluated before and 3, 24, and 48 h after therapy. There was a significant prolongation of template bleeding time from 290 s to 400 s. The amplitude of spontaneous and induced platelet aggregation remained unchanged. In four of the 10 patients initially high plasma concentrations of beta-TG and PF4, and high serum concentrations of TxB2, decreased, indicating an effect of molsidomine in states of hyperreactive platelets.