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Published on: February 8, 2019
Characteristics of Vogt-Koyanagi-Harada disease in a French cohort: ethnicity, systemic manifestations, and HLA
S Abad1, D Monnet, S Caillat-Zucman
1Service de Médecine Interne, Laboratoire de recherche clinique et thérapeutique UPRES EA3409, Université Paris XIII, Faculté Léonard de Vinci, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Paris, France. sebastien.abad@avc.ap-hop-paris.fr
Purpose:
To assess in patients followed in a French referral center the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease and the HLA-DRB1*04 genotype.
Methods:
Patients previously diagnosed as having VKH disease were re-evaluated in a cross-sectional study using the VKH Committee's revised criteria. High-resolution HLA-DRB1 genotyping was performed.
Results:
Eleven white patients satisfied ophthalmologic diagnostic criteria. All originated from Mediterranean countries. Nine and 3 patients had neurologic and/or cutaneous abnormalities, respectively. Among DRB1*04-positive patients, the HLA-DRB1*0405 subtype was 71%.
Conclusion:
These VKH patients predominantly had an incomplete form. The HLA-DRB1*0405 subtype allele was enriched in a group of Mediterranean stock.
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