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Related Experiment Video

Updated: Jul 6, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Guideline 'Renal cell carcinoma'].

P F A Mulders¹, A H Brouwers, C A Hulsbergen-van der Kaa

¹Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen. p.mulders@uro.umcn.nl

Nederlands Tijdschrift Voor Geneeskunde

|April 3, 2008

Summary

This guideline provides updated recommendations for diagnosing and treating renal cell carcinoma (kidney cancer). It emphasizes CT imaging, laparoscopic surgery, and specific treatments for metastatic disease, improving patient outcomes.

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Area of Science:

Urology
Oncology
Radiology

Context:

Renal cell carcinoma (kidney cancer) affects over 1500 people annually in the Netherlands.
Existing clinical practices for diagnosis and treatment require updated recommendations.

Purpose:

To provide evidence-based clinical practice recommendations for renal cell carcinoma (kidney cancer).
To standardize diagnosis, including imaging and pathology.
To outline effective treatment strategies, including surgery and systemic therapies.

Summary:

Recommends CT imaging for diagnosis; advises against scintigraphy.
Supports laparoscopic radical nephrectomy for localized tumors (T1-T3) due to reduced morbidity.
Highlights the benefit of tumor removal in metastatic renal cell carcinoma and metastasectomy for solitary metastases.
Indicates limited efficacy of cytotoxic agents, but suggests Interferon-alpha for specific patient groups.

Impact:

Aims to improve diagnostic accuracy and treatment efficacy for renal cell carcinoma.
Promotes minimally invasive surgical techniques, potentially reducing patient recovery time and complications.
Provides a standardized approach to managing renal cell carcinoma, enhancing patient survival and quality of life.