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Updated: Jul 6, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
A multinational investigation of time and traveling costs in attending anticoagulation clinics
Sue Jowett1, Stirling Bryan, Isabelle Mahé
1Health Economics Facility, Health Services Management Center, University of Birmingham, Birmingham, UK. s.jowett@bham.ac.uk
Insights
Patients face significant time and travel expenses for anticoagulation clinic visits, impacting both personal finances and societal costs. These economic burdens vary substantially by country, highlighting the need for a comprehensive cost analysis.
Area of Science:
- Pharmacoeconomics
- Health Services Research
- Clinical Pharmacy
Background:
- Anticoagulation therapy, essential for atrial fibrillation patients to prevent ischemic stroke, necessitates regular monitoring and dose adjustments.
- Attending anticoagulation clinics involves patient time and travel, contributing to overall healthcare costs.
Purpose of the Study:
- To quantify the patient-incurred time and travel expenses associated with attending anticoagulation clinics.
- To assess the societal costs related to these clinic visits.
Main Methods:
- A questionnaire survey was administered to patients on warfarin therapy across primary and secondary care clinics in Australia, France, Portugal, Spain, Sweden, and the UK.
- Data collected included transport methods, travel expenses, time spent at clinics, and impact on employment.
- Cost calculations considered patient expenses and the value of lost working and leisure time, including companion time.
Main Results:
- Analysis of 381 patient questionnaires revealed significant variation in mean patient costs per visit, ranging from €6.9 in France to €20.5 in Portugal.
- Time costs, representing lost working and leisure time, constituted the primary cost driver in most participating countries.
- Mean societal time costs per visit ranged from €5.6 in France to €31.7 in Portugal.
Conclusions:
- Patients incur substantial economic costs when attending anticoagulation clinics, with considerable international variation.
- These findings underscore the importance of a broad economic perspective in evaluating the cost-effectiveness of anticoagulation treatments like warfarin.
Objectives:
Anticoagulation is used in patients with atrial fibrillation to reduce the risk of ischemic stroke. The therapy requires regular monitoring and, frequently, dose adjustment. This study aimed to determine the time and traveling costs that patients incur to themselves and society in attending anticoagulation clinics.
Methods:
A subset of patients from 105 primary and secondary care clinics allocated to the warfarin arm of SPORTIF III (patients from Australia, France, Portugal, Spain, Sweden, and the UK) completed a questionnaire. Patients indicated the type of transport used for clinic visits, and estimated traveling expenses. Patients were also asked to estimate total traveling and clinic attendance time, and to confirm whether they were currently employed and whether they had to give up time from work to attend the clinic. Time cost of companions was also taken into consideration. Cost per visit was calculated (euro, 2003 prices).
Results:
Questionnaires for a total of 381 patients were analyzed, with the majority of patients from Sweden (n = 130) and the UK (n = 101). Mean cost to patients varied widely between countries, ranging from euro6.9 (France) to euro20.5 (Portugal) per visit. For most countries, time costs (value of lost working and leisure time) were the main driver of costs. Mean time cost to society ranged from euro5.6 (France) to euro31.7 (Portugal) per visit.
Conclusions:
Patients incur considerable costs when visiting anticoagulation clinics, and these costs vary by country. The results suggest the importance of taking a broad economic perspective when considering the cost-effectiveness of warfarin.
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