Related Experiment Video
Updated: Jul 6, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Warfarin-induced allergic interstitial nephritis and leucocytoclastic vasculitis
1The Ohio State University College of Medicine, Columbus, Ohio , USA. Kaps2003@gmail.com
Abstract:
Warfarin sodium has been associated with leucocytoclastic vasculitis and has once been associated with allergic interstitial nephritis. Hypersensitivity to warfarin sodium simultaneously resulting in allergic interstitial nephritis and leucocytoclastic vasculitis has not yet been previously reported. We present a 48-year-old man who was on warfarin sodium for 2 months and presented with acute renal failure and reddish purplish macules on his hypogastric regions and lower extremities bilaterally. Kidney biopsy showed allergic interstitial nephritis and punch skin biopsy showed leucocytoclastic vasculitis. Both biopsies also showed high eosinophil count, highly suggestive of a drug-induced reaction. After a negative comprehensive work-up and the absence of other recent medication changes, our patient was determined to have allergic interstitial nephritis and leucocytoclastic vasculitis secondary to warfarin sodium.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Drug Toxicity: Allergic Reactions
Endocarditis II: Clinical Features of Infective Endocarditis
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Venous Thrombosis III: Interprofessional Care