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Intracrinology.

F Labrie1

  • 1Department of Molecular Endocrinology, Laval University, Quebec, Canada.

Molecular and Cellular Endocrinology
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Peripheral tissues synthesize most androgens in men and estrogens in women from adrenal precursors. This discovery of intracrinology highlights steroidogenic enzymes as key targets for treating hormone-sensitive cancers.

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Area of Science:

  • Endocrinology and hormone action.
  • Molecular biology and gene expression.
  • Oncology and cancer therapeutics.

Background:

  • A significant portion of androgens in men (40%) and the majority of estrogens in women (75% pre-menopause, ~100% post-menopause) are synthesized in peripheral tissues.
  • This synthesis occurs from precursor steroids originating from the adrenal glands.
  • The expression of genes for steroid-forming and metabolizing enzymes in various peripheral tissues is well-documented.

Purpose of the Study:

  • To introduce intracrinology as a new area of hormone action.
  • To highlight the role of peripheral steroid synthesis in hormone-dependent diseases.
  • To propose steroidogenic and metabolizing enzymes as therapeutic targets.

Main Methods:

  • Analysis of androgen and estrogen synthesis pathways in peripheral tissues.

Related Experiment Videos

  • Examination of gene expression patterns for relevant enzymes in various tissues.
  • Review of existing literature on intracrinology and steroid metabolism.

    • Main Results:

    • Demonstrated significant peripheral synthesis of androgens and estrogens.
    • Identified widespread expression of key steroidogenic and metabolizing enzymes in peripheral tissues.
    • Established the foundation for intracrinology as a distinct field of study.

    Conclusions:

    • Intracrinology, focusing on peripheral hormone synthesis, is a crucial area of endocrine research.
    • Targeting steroidogenic and steroid metabolizing enzymes offers a promising therapeutic strategy.
    • Novel therapies for steroid-sensitive diseases, especially breast and prostate cancer, can be developed by targeting these enzymes.