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Published on: February 10, 2023
Venous thromboembolism in children
Neil A Goldenberg1, Timothy J Bernard
1Mountain States Regional Hemophilia and Thrombosis Center, P.O. Box 6507, Mail-Stop F-416, Aurora, CO 80045-0507, USA. neil.goldenberg@uchsc.edu
Insights
Pediatric venous thromboembolism (VTE) is a growing concern due to increased survival rates and invasive procedures. This review covers VTE causes, diagnosis, and management in children.
Area of Science:
- Pediatric medicine
- Hematology
- Vascular medicine
Background:
- Improved pediatric survival from critical illnesses.
- Increased use of invasive vascular procedures and devices in children.
- Growing recognition of vascular events in the pediatric population.
Purpose of the Study:
- To provide background on the etiology and epidemiology of pediatric venous thromboembolism (VTE).
- To discuss clinical characterization, diagnostic evaluation, and management strategies for pediatric VTE.
- To consider prognostic indicators, long-term outcomes, and identify areas for future research.
Main Methods:
- Literature review focusing on pediatric venous thromboembolism.
- Synthesis of evidence on etiology, epidemiology, diagnosis, and management.
- Analysis of prognostic indicators and long-term outcomes in pediatric VTE.
Main Results:
- Venous thromboembolism (VTE) is an increasingly recognized pediatric concern.
- Comprehensive approaches to diagnosis and management are essential for pediatric VTE.
- Understanding prognostic indicators and long-term outcomes is crucial for effective care.
Conclusions:
- Pediatric venous thromboembolism (VTE) requires careful consideration due to rising incidence.
- Evidence-based strategies for diagnosis and management are critical for improving outcomes.
- Further research is needed to address knowledge gaps in pediatric VTE.
Abstract:
With improved pediatric survival from serious underlying illnesses, greater use of invasive vascular procedures and devices, and a growing awareness that vascular events occur among the young, venous thromboembolism (VTE) increasingly is recognized as a critical pediatric concern. This review provides background on etiology and epidemiology in this disorder, followed by an in-depth discussion of approaches to the clinical characterization, diagnostic evaluation, and management of pediatric VTE. Prognostic indicators and long-term outcomes are considered, with emphasis on available evidence underlying current knowledge and key questions for further investigation.
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