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06:21
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
UFT (tegafur-uracil) in rectal cancer
E Casado1, P Pfeiffer2, J Feliu3
1Department of Medical Oncology, Hospital Infanta Sofía, Madrid, Spain.
Summary
Oral UFT (tegafur-uracil) offers a convenient and effective alternative to continuous infusion 5-fluorouracil for locally advanced rectal cancer (LARC) treatment. Studies show UFT is comparable to 5-FU and capecitabine, with a favorable side-effect profile.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Total mesorectal excision and perioperative chemoradiotherapy (5-FU) are standard for localized rectal cancer.
- Continuous infusion 5-FU (CI 5-FU) is effective but inconvenient and costly.
- Oral fluoropyrimidines, such as UFT (tegafur-uracil), present advantages over intravenous 5-FU.
Purpose of the Study:
- To review clinical studies on the efficacy and tolerability of UFT in locally advanced rectal cancer (LARC).
- To evaluate UFT's role in perioperative settings for LARC treatment.
Main Methods:
- Systematic review of published articles and abstracts on UFT in LARC.
- Inclusion of pre- and postoperative studies in patients with newly diagnosed or recurrent LARC.
Main Results:
- Preoperative UFT combined with radiotherapy is effective and well-tolerated.
- Adjuvant UFT demonstrates improved survival and reduced distant relapse compared to surgery alone.
- UFT's efficacy is comparable to 5-FU and capecitabine, with a favorable side-effect profile.
Conclusions:
- UFT is a valuable option for perioperative LARC treatment.
- Combining UFT with targeted agents may further enhance patient outcomes.
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