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Related Concept Videos

Sample Handling01:02

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

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Updated: Jul 6, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

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Published on: November 30, 2022

The UK Biobank sample handling and storage validation studies.

Tim C Peakman1, Paul Elliott

  • 1UK Biobank, Spectrum Way, Adswood, Stockport, Cheshire SK3 0SA, UK. tim.peakman@ukbiobank.ac.uk

International Journal of Epidemiology
|April 18, 2008
PubMed
Summary

UK Biobank blood and urine samples remain stable for 24 hours at 4°C, ensuring resource integrity. Storage protocols are validated for future disease research, supporting genetic and lifestyle studies.

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Area of Science:

  • Biomedical Research
  • Genomics and Proteomics
  • Epidemiology

Background:

  • UK Biobank is a major prospective study investigating genetic, environmental, and lifestyle factors in major diseases.
  • The study involves collecting biological samples from 500,000 individuals aged 40-69.
  • Robust sample handling and storage are critical for the scientific value of the UK Biobank resource.

Purpose of the Study:

  • To validate the sample handling and storage protocol for the UK Biobank project.
  • To assess the impact of pre-processing time and temperature on sample stability.
  • To ensure the integrity of biological samples for future research.

Main Methods:

  • Blood and urine samples from 40 volunteers were processed immediately or stored at 4°C (or 18°C for specific tubes) for 12, 24, or 36 hours.
  • A subset of samples underwent short-term freezing (-80°C for 20 days) and thawing.
  • Sample stability was evaluated using a variety of biochemical and metabonomic assays.

Main Results:

  • Samples maintained at 4°C were stable for at least 24 hours across numerous assays.
  • Minor but significant changes were detected in metabonomic studies for samples stored at 4°C for 36 hours.
  • No degradation was observed for biochemical assays after controlled short-term freezing and thawing.
  • Whole blood stored at 18°C for 24 hours is suitable for viral immortalization.

Conclusions:

  • The validation studies support the adopted sample handling and storage procedures for the UK Biobank project.
  • The findings provide confidence in the quality and usability of UK Biobank samples for research.
  • The established protocols ensure the long-term scientific utility of the UK Biobank resource.