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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Clopidogrel use in coronary heart disease and percutaneous coronary intervention

Andrew D Atiemo1, Marlene S Williams

  • 1Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD 21224, USA.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|April 3, 2008
PubMed

Insights

Clopidogrel effectively manages atherothrombosis by blocking adenosine diphosphate. This review covers its mechanism, clinical trials, and the implications of clopidogrel resistance in cardiovascular disease.

Area of Science:

  • Cardiology
  • Pharmacology
  • Thrombosis

Background:

  • Antiplatelet therapy is crucial for managing atherothrombosis.
  • Clopidogrel, a thienopyridine, is a widely used antiplatelet medication.
  • Its efficacy is established in various cardiovascular conditions.

Purpose of the Study:

  • To review the pharmacology and mechanism of action of clopidogrel.
  • To summarize key clinical trials evaluating clopidogrel in coronary heart disease.
  • To discuss clopidogrel resistance and its clinical significance.

Main Methods:

  • Literature review of major clinical trials.
  • Analysis of clopidogrel's pharmacological properties.
  • Examination of studies on antiplatelet resistance.

Main Results:

  • Clopidogrel inhibits adenosine 5' diphosphate (ADP) binding to platelet receptors.
  • Clinical trials confirm clopidogrel's benefit in atherosclerosis and acute coronary syndromes.
  • Clopidogrel resistance is a recognized phenomenon with potential clinical impact.

Conclusions:

  • Clopidogrel is a vital agent in managing atherothrombosis.
  • Understanding its mechanism and clinical applications is essential.
  • Further research into clopidogrel resistance may optimize patient outcomes.

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