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Interleukin 1 signal transduction
1Cytokine Biochemistry Department, Strangeways Research Laboratory, Cambridge, UK.
Agents and Actions. Supplements
|January 1, 1991
Abstract:
Interleukin 1 signals through an 80kDa receptor to change protein kinase activity in fibroblasts. Two increases in protein phosphorylation have been identified: the EGF receptor and the small heat shock protein (hsp 27). Both involve serine and are similarly transient (maximal 5-15 minutes). The kinase activity differs from PKA or C. Hsp 27 can be used for its assay in extracts of stimulated cells.