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Published on: September 15, 2017
The ectopic adrenocorticotropic hormone syndrome in carcinoid tumors
Poorya Fazel1, Prasanthi Ganesa, Robert G Mennel
1Departments of Internal Medicine (Fazel), Oncology (Ganesa, Mennel), and Pathology (Austin), Baylor University Medical Center, Dallas, Texas.
Abstract:
Ectopic production of adrenocorticotropic hormone by carcinoid tumors is relatively uncommon and may not be recognized by physicians. This report describes a woman who had Cushing syndrome from the ectopic secretion of adrenocorticotropic hormone by a carcinoid tumor. Her cause of death was a pneumonia that may have been secondary to her untreated hypercortisolism. There are threeinstructive elements of this case: 1) the recognition of Cushing syndrome, 2) the association of Cushing syndrome with low-grade (carcinoid tumors) as well as with high-grade (small cell carcinoma) neuroendocrine tumors, and 3) the need to treat the hypercortisolism as well as the tumor.
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