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Updated: Aug 8, 2026
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Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
Nephrotoxicity from chemotherapy: prevention and management
1Section of Hematology/Oncology, University of Chicago.
Oncology (Williston Park, N.Y.)
|October 1, 1991
Summary
Certain chemotherapy drugs can harm kidney function, leading to nephrotoxicity. Adequate hydration is crucial for preventing and reversing this chemotherapy side effect.
Area of Science:
- Nephrology
- Oncology
- Pharmacology
Background:
- Nephrotoxicity is a significant adverse effect of antineoplastic chemotherapy.
- Several chemotherapy agents are known to cause kidney damage.
Purpose of the Study:
- To review the nephrotoxic effects of specific chemotherapy drugs.
- To highlight the role of hydration in managing chemotherapy-induced kidney damage.
Main Methods:
- Literature review of studies on chemotherapy-induced nephrotoxicity.
- Analysis of the impact of various antineoplastic agents on kidney function.
- Discussion of combination therapies and their renal effects.
Main Results:
- Plicamycin, methotrexate, mitomycin C, nitrosoureas, 5-azacytidine, cisplatin, ifosfamide, carboplatin, and gallium nitrate can all impair kidney function.
- The risk of nephrotoxicity may be influenced by drug combinations and other agents.
- Adequate hydration is a key factor in mitigating and potentially reversing drug-induced nephrotoxicity.
Conclusions:
- Understanding the nephrotoxic potential of individual chemotherapy drugs is essential for patient safety.
- Proactive management, including hydration, can help prevent or reduce kidney damage during cancer treatment.
- Further research into nephroprotective strategies during chemotherapy is warranted.
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