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Updated: Jul 6, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Management of patients with refractory migraine and PFO: Is MIST I relevant?
1UCLA-David Geffen School of Medicine, BL-394 CHS, 10833 LeConte Ave., Los Angeles, CA 90095-1717, USA.
Abstract:
The results of the randomized clinical trial entitled: Migraine Intervention with Starflex Technology (MIST), produced surprising and disappointing results on the effect of PFO closure to decrease migraine headaches. There have been allegations of misrepresentation of the effectiveness of this device. These issues have significant implications in how randomized clinical trials are performed that will impact current and future planned trials of PFO closure to treat migraine headaches.
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