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Updated: Jul 6, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Estrogen receptor and breast MR imaging features: a correlation study.

Jeon-Hor Chen¹, Hyeon-Man Baek, Orhan Nalcioglu

¹Center for Functional Onco-Imaging, School of Medicine, University of California, Irvine, California 92697, USA. jeonhc@uci.edu

Journal of Magnetic Resonance Imaging : JMRI

|April 3, 2008

Summary

Estrogen receptor (ER) negative breast cancers show more aggressive features on MRI, including larger tumor size and enlarged axillary lymph nodes, compared to ER positive cancers. These imaging findings suggest potentially poorer cellular differentiation or increased angiogenesis in ER negative tumors.

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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

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Published on: February 21, 2014

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Area of Science:

Radiology and Oncology
Breast Imaging
Cancer Research

Background:

Estrogen receptor (ER) status is a critical factor in breast cancer classification and treatment.
Understanding the imaging characteristics associated with ER status can aid in diagnosis and prognosis.
Magnetic Resonance Imaging (MRI) offers detailed visualization of breast tumor morphology and behavior.

Purpose of the Study:

To compare MRI features between estrogen receptor (ER) positive and negative invasive ductal carcinoma (IDC).
To investigate differences in tumor morphology, enhancement kinetics, and lymph node status based on ER status.

Main Methods:

Retrospective analysis of breast MRI from 90 patients with IDC (51 ER positive, 39 ER negative).
Evaluation of tumor morphology and dynamic contrast-enhanced (DCE) kinetics using BI-RADS MRI lexicon.
Assessment of axillary lymph node status via MRI and pathology, and choline (Cho) detection using MR spectroscopy (MRS).

Main Results:

ER negative breast cancers were significantly larger (3.6 cm vs. 1.8 cm) and more likely to show non-mass type enhancements (P < 0.005).
Enlarged axillary lymph nodes were more frequent on MRI in ER negative patients (P < 0.05).
While trends suggested more malignant enhancement kinetics and choline detection in ER negative cancers, these did not reach statistical significance.

Conclusions:

ER negative breast cancer exhibits more aggressive imaging features on MRI, including larger size and more frequent enlarged axillary nodes.
These MRI findings may correlate with poorer cellular differentiation and/or higher angiogenesis in ER negative tumors.
Further research is warranted to explore the predictive value of these MRI characteristics for ER status and patient outcomes.