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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Relationship between choline and apparent diffusion coefficient in patients with gliomas.

Inas S Khayal1, Forrest W Crawford, Suja Saraswathy

  • 1University of California, San Francisco, California, USA. inas.khayal@radiology.ucsf.edu

Journal of Magnetic Resonance Imaging : JMRI
|April 3, 2008
PubMed
Summary

Diffusion weighted imaging (DWI) and magnetic resonance spectroscopic imaging (MRSI) reveal differing relationships between apparent diffusion coefficients (ADC) and choline levels in Grade II versus Grade IV gliomas.

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Area of Science:

  • Neuro-oncology
  • Radiology
  • Biophysics

Background:

  • Gliomas are primary brain tumors with varying grades of malignancy.
  • Diffusion weighted imaging (DWI) and proton magnetic resonance spectroscopic imaging (MRSI) are advanced neuroimaging techniques.
  • Apparent diffusion coefficients (ADC) and choline levels are quantitative imaging biomarkers.

Purpose of the Study:

  • To investigate the correlation between ADC values from DWI and choline levels from MRSI in newly diagnosed gliomas.
  • To analyze these relationships in distinct anatomical regions for Grade II and Grade IV gliomas.

Main Methods:

  • 37 patients with Grade II and 28 with Grade IV glioma underwent 1.5T MRI with 3D MRSI and DWI.
  • Region and voxel level analyses were performed using Spearman rank correlation.
  • Median normalized ADC and choline levels were compared within specific tumor regions.

Main Results:

  • No significant correlation between ADC and choline was observed in Grade II gliomas at either region or voxel level.
  • Grade IV gliomas showed no correlation in contrast-enhancing or necrotic regions.
  • A significant negative correlation was found in heterogeneous non-enhancing and combined regions of Grade IV gliomas.

Conclusions:

  • The relationship between ADC and choline differs between Grade II and Grade IV gliomas.
  • Tumor heterogeneity in Grade IV gliomas appears to significantly influence the ADC-choline correlation.