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Updated: Jul 6, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
Longitudinal analysis of pulmonary function in adults with sickle cell disease
Joshua J Field1, Jeffrey Glassberg, Annette Gilmore
1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. jfield@im.wustl.edu
Abstract:
Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.
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