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Updated: Jul 6, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Published on: October 24, 2018
[Medical and psychological prevention of stress-induced premature aging]
Abstract:
We studied the efficiency of the method complex for psychotherapy (psychocorrection) of those who suffer from post-traumatic stress disorders (PTSD) with the purpose of prevention and reduction of psychovegetative disorders and aging pace which would prevent from early disability and death. We studied 82 male patients suffering from post-traumatic stress disorder aged from 22 to 35 who endured combat psychologic traumatic experience. In our study we used 4 method approaches enabling to assess a functional state of an organism sequentially and fully. Those included: 1) a clinical psychopathological approach; 2) an experimental psychological approach; 3) a spectral analysis of the heart rate variability; 4) assessment of biological age dimensions. It was ascertained that PTSD can be seen as one of the factors increasing BA (biological age) and aging pace of people who experienced extreme situations. Our study proved that combined methods of psychotherapeutic rehabilitation also normalize parameters of vegetative heart rate regulation circuit. It is shown that positive changes in psychovegetative sphere achieved in people suffering from PTSD decrease an organism's aging pace.
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