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Updated: Jul 6, 2026
10:18
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
[Primary central nervous system lymphoma--a single center experience]
Zdravko Mitrović1, Ivo Radman, Igor Aurer
1Zavod za hematologiju, Klinika za unutarnje bolesti Medicinskog fakulteta, KBC Zagreb..
Lijecnicki Vjesnik
|April 4, 2008
Summary
Primary CNS lymphoma (PCNSL) is rare. High-dose methotrexate showed promise in younger patients, but older adults with PCNSL face poor prognoses despite treatment.
Area of Science:
- Oncology
- Neurology
- Hematology
Context:
- Primary CNS lymphoma (PCNSL) is a rare extranodal non-Hodgkin's lymphoma.
- Limited data exists on treatment outcomes for PCNSL, particularly in specific patient demographics.
Purpose:
- To retrospectively analyze treatment outcomes for PCNSL patients.
- To evaluate the efficacy of high-dose methotrexate and other treatment modalities.
Summary:
- Twenty PCNSL patients were treated over eight years.
- 13 patients received high-dose methotrexate (4 g/m2); others had different chemotherapy or radiotherapy.
- Complete remission was 40%, and 2-year survival was 30%, with no treatment-related deaths.
Impact:
- High-dose methotrexate is effective for younger PCNSL patients (<60 years).
- Older PCNSL patients have a poor prognosis regardless of treatment.
- Findings inform treatment strategies and prognosis for PCNSL.
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