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Published on: October 2, 2015
A new peritoneal carcinomatosis model in cyclosporine immunosuppressed rats
Javed Akhter1, Peng Yao, Loreena A Johnson
1University of New South Wales, Department of Surgery, St. George Hospital, Sydney, Australia.
Abstract:
Colorectal cancer (CRC) cells (HT29) were injected into the intraperitoneal (i.p.) cavity of immunosuppressed male Sprague Dawley rats. Immunosuppression was achieved via a daily i.p. injection of cyclosporine 35 mg/kg/day. Three groups of rats (n = 6 per group) were injected with 20, 50 or 100 million HT29 cells. All animals developed tumours indicating that this animal model may prove useful for future research in human colorectal carcinomatosis.
