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Updated: Jul 6, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
Where shall we meet? A role for genome organisation and nuclear sub-compartments in mediating interchromosomal
Cameron S Osborne1, Christopher H Eskiw
1Laboratory of Chromatin and Gene Expression, Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom. cameron.osborne@bbsrc.ac.uk
Abstract:
A recent spate of examples of specific interactions between loci on separate chromosomes in mammalian nuclei has illuminated another layer of complexity in gene regulation. As the specifics of the cross-talk between interacting loci are worked out, it is also important to consider exactly how, when and where loci can ever reliably find each other within such an intricate environment. Answers may lie in how the genome is organised in relation to itself and to specialised nuclear sub-compartments. Here, we discuss how such specialised nuclear bodies may have the potential to specifically sequester loci and provide a context where interchromosomal communications can occur.
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