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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

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Related Experiment Video

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Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
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Published on: October 27, 2023

Multi-targeted therapy by curcumin: how spicy is it?

Ajay Goel1, Sonia Jhurani, Bharat B Aggarwal

  • 1Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA.

Molecular Nutrition & Food Research
|April 4, 2008
PubMed
Summary

Curcumin, a compound in turmeric, offers a multitargeted therapy approach for diseases. Despite poor absorption, its safety and efficacy in clinical trials suggest potential for cancer treatment.

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Area of Science:

  • Phytochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Traditional medicines often lack identified active components and molecular targets.
  • Curcumin, derived from turmeric, is an exception with well-studied biological activities.
  • Existing cancer therapies often target single pathways, leading to resistance.

Purpose of the Study:

  • To review the molecular mechanisms of curcumin's action.
  • To compare curcumin's multitargeted approach with single-targeted cancer therapies.
  • To highlight curcumin's potential as a safe and inexpensive therapeutic agent.

Main Methods:

  • Review of existing scientific literature on curcumin's molecular targets and effects.
  • Comparative analysis of curcumin's efficacy against single-targeted therapies.
  • Examination of safety and pharmacokinetic data from human clinical trials.

Main Results:

  • Curcumin down-regulates multiple cancer-related targets including cyclooxygenase-2, HER2, and vascular endothelial cell growth factor.
  • Curcumin induces apoptosis and modulates cell survival and regulatory proteins (p53, p21, p27).
  • Physiologically achievable concentrations of curcumin demonstrate chemopreventive and chemotherapeutic potential.

Conclusions:

  • Curcumin's multitargeted action offers a promising strategy for disease treatment, particularly cancer.
  • Curcumin is safe, inexpensive, and effective even at low concentrations, presenting an advantage over single-targeted drugs.
  • Further research into curcumin's therapeutic applications is warranted based on its broad molecular activity.