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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
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Reactive versus neoplastic bone marrow: problems and pitfalls.

Robert P Hasserjian1

  • 1Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115, USA. rhasserjian@partners.org

Archives of Pathology & Laboratory Medicine
|April 4, 2008
PubMed
Summary
This summary is machine-generated.

Bone marrow examination requires careful integration of biopsy histology, aspirate cytology, and peripheral blood smear analysis. Optimal sample handling and clinical context are crucial for accurate diagnosis of bone marrow diseases.

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Area of Science:

  • Hematopathology
  • Diagnostic Pathology

Background:

  • Bone marrow examination presents unique diagnostic challenges due to its semi-solid nature and dynamic interaction with the lymphohemopoietic system.
  • Accurate diagnosis of bone marrow diseases often relies on specialized ancillary studies.

Purpose of the Study:

  • To outline the critical components and considerations for optimal bone marrow examination.
  • To emphasize the importance of integrating various sample types and clinical information for accurate disease diagnosis.

Main Methods:

  • Review of bone marrow biopsy histology.
  • Analysis of bone marrow aspirate smear cytology.
  • Examination of peripheral blood smear.
  • Consideration of ancillary special studies and clinical context.

Main Results:

  • Optimal procurement and processing of bone marrow samples are essential for maximizing diagnostic information.
  • Distinguishing reactive from neoplastic bone marrow processes requires a combination of high-quality samples and clinical data.

Conclusions:

  • A comprehensive approach integrating histology, cytology, peripheral blood analysis, and clinical context is vital for accurate bone marrow disease diagnosis.
  • Awareness of potential diagnostic pitfalls is necessary for pathologists interpreting bone marrow examinations.