Integrin scintimammography using a dedicated breast imaging, solid-state gamma-camera and (99m)Tc-labelled NC100692
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Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Tore Bach-Gansmo1, Trond V Bogsrud, Arne Skretting
1Department of Nuclear Medicine, Institute for Surgical Sciences, University of Bergen, Bergen, Norway. ingolv.tore.bach-gansmo@helse-bergen.no
Objective:
Integrin scintimammography with NC100692 and a dedicated gamma-camera, LumaGEM, based on semi-conductor technology, was performed to investigate the detection ability of this combination in breast cancer.
Methods:
Eight patients with a high suspicion of breast cancer were administered 600-750 MBq (99m)Tc-labelled NC100629. Two acquisitions using a cranio-caudal and a lateral view were used, with moderate compression of the breast.
Results:
LumaGEM scintigraphy revealed 9 of 11 malignancies, sized 6-20 mm. Two lesions in patients with multicentric disease were not diagnosed, one of which measured only 2.5 mm. In one patient, the procedure was inconclusive, due to major breast hypertrophy.
Conclusion:
The combined use of NC100629 and a dedicated gamma-camera for breast imaging was highly effective in diagnosing breast cancer.
