Human dirofilariasis due to Dirofilaria repens mimicking a scrotal tumor

Dirofilariasis due to Dirofilaria repens is a rare anthropozoonotic disease, with dogs and cats being the definite hosts for this parasite. This worm is transmitted by various species of mosquitoes and usually presents as a subcutaneous nodule. Human cases have been reported from all around the Mediterranean, Eastern Europe, and Central and Southern Asia. In the present case involving a 28-year-old patient of Tunisian origin, infection manifested as a nodule in the left epididymis. In the context of increasing international travel and migration, dirofilariasis is a diagnosis that should be kept in mind when treating patients who have spent some time in endemic areas and present with unclear subcutaneous or scrotal nodules.