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Enuresis is a common and persistent problem among children and young adults with sickle cell anemia

Joshua J Field1, Paul F Austin, Ping An

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. jfield@im.wustl.edu

Urology
|April 4, 2008
PubMed

Insights

Enuresis and nocturia are common in children with sickle cell anemia (SCA). These conditions persist into adulthood and are not linked to increased pain or acute chest syndrome (ACS) episodes.

Area of Science:

  • Pediatrics
  • Hematology
  • Urology

Background:

  • Enuresis (bedwetting) and nocturia (frequent urination at night) are common in children.
  • Sickle cell anemia (SCA) is a genetic blood disorder that can affect multiple organ systems.
  • The prevalence and impact of enuresis and nocturia in individuals with SCA are not well-established.

Purpose of the Study:

  • To determine the prevalence of enuresis and nocturia in children and young adults with SCA.
  • To investigate the association between enuresis/nocturia and SCA-related morbidity, including pain and acute chest syndrome (ACS).

Main Methods:

  • Analysis of a prospective infant cohort of African-American children with SCA.
  • Inclusion of participants enrolled before 6 months of age with completed questionnaires on enuresis and nocturia.
  • Data collection on enuresis and nocturia prevalence and correlation with SCA-related complications.

Main Results:

  • Out of 213 participants, 33% experienced enuresis.
  • Enuresis was most prevalent in children aged 6-8 years (42%) and persisted in young adults (9% aged 18-20).
  • Nocturia was reported by 79% of participants. No association was found between enuresis/nocturia and increased pain or ACS episodes.

Conclusions:

  • Enuresis and nocturia are highly prevalent in children and young adults with SCA.
  • These urinary symptoms are more persistent in adults with SCA compared to the general population.
  • Enuresis and nocturia in SCA patients are not associated with increased pain or ACS episodes.
Abstract

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