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Updated: Jul 6, 2026
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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
The cancer biomarker problem.
1Howard Hughes Medical Institute, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.
Nature
|April 4, 2008
Summary
Genomic technologies advance cancer understanding by characterizing tumors. Identifying cancer biomarkers is crucial for predicting patient response to targeted therapies.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Genomic technologies provide deep insights into cancer at the molecular level.
- Clinical successes demonstrate the utility of molecular information in designing targeted cancer drugs.
- A key challenge remains in identifying reliable biomarkers for targeted therapy selection.
Purpose of the Study:
- To highlight the role of genomic technologies in cancer research.
- To emphasize the importance of biomarkers in personalized cancer medicine.
- To address the barrier in identifying predictive biomarkers for targeted therapies.
Main Methods:
- Characterization of tumors using advanced genomic technologies.
- Analysis of clinical data to correlate molecular profiles with treatment outcomes.
- Literature review on biomarker discovery and validation strategies.
Main Results:
- Genomic characterization enables a comprehensive understanding of tumor biology.
- Targeted drug development is significantly advanced by molecular insights.
- Biomarker identification is essential for optimizing targeted therapy efficacy.
Conclusions:
- Genomic technologies are pivotal in advancing cancer research and treatment.
- Effective identification of cancer biomarkers is critical for the success of targeted therapies.
- Overcoming biomarker identification challenges will accelerate progress in personalized oncology.
