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Strontium ranelate does not stimulate bone formation in ovariectomized rats.

R K Fuchs¹, M R Allen, K W Condon

¹Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA. rfuchs@iupui.edu

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

|April 4, 2008

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Strontium ranelate (SrR) did not stimulate bone formation or improve bone strength in ovariectomized rats, even with normal calcium intake. These findings suggest SrR may not be effective for treating osteoporosis in this model.

Area of Science:

Bone Biology and Pharmacology
Osteoporosis Research

Background:

Strontium ranelate (SrR) is investigated for dual anti-resorptive and anabolic effects in postmenopausal osteoporosis.
The influence of dietary calcium on SrR efficacy requires further evaluation.

Purpose of the Study:

To assess the skeletal effects of strontium ranelate (SrR) in an ovariectomized (OVX) rat model.
To determine the impact of dietary calcium levels on SrR's efficacy.

Main Methods:

Ovariectomized (OVX) and SHAM-operated rats were treated with SrR (25 or 150 mg/kg/day) or vehicle for 90 days.
Animals were fed either a low (0.1%) or normal (1.19%) calcium diet.
Bone histomorphometry, DXA, micro-CT, mechanical testing, and strontium levels were analyzed.

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Main Results:

SrR did not enhance bone formation on trabecular or periosteal surfaces at either dose.
Bone resorption was not inhibited by SrR, irrespective of calcium intake.
No improvements in bone mass, volume, or strength were observed with SrR administration.

Conclusions:

Strontium ranelate (SrR) at 25 and 150 mg/kg/day failed to stimulate an anabolic bone response in OVX rats.
SrR did not improve the biomechanical properties of bone in this osteoporosis model.
Dietary calcium did not influence the lack of anabolic or anti-resorptive effects of SrR.