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Related Experiment Video

Updated: Jul 6, 2026

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Published on: December 13, 2019

Prostate stem cells and benign prostatic hyperplasia.

John T Isaacs¹

¹Department of Oncology, The Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA. isaacjo@jhmi.edu

|April 4, 2008

Summary

This summary is machine-generated.

This study proposes an acute therapy for benign prostatic hyperplasia (BPH) using temporary androgen deprivation and radiation. This approach aims to avoid the chronic side effects and costs associated with current daily BPH treatments.

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Last Updated: Jul 6, 2026

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Published on: December 13, 2019

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

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Murine Prostate Micro-dissection and Surgical Castration

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Published on: May 11, 2016

Area of Science:

Urology
Oncology
Endocrinology

Background:

Current pharmacological treatments for symptomatic benign prostatic hyperplasia (BPH) involve daily medications like alpha-blockers and 5-alpha-reductase inhibitors.
These chronic treatments present challenges including daily adherence, significant financial costs, and quality of life issues.

Purpose of the Study:

To explore the feasibility of an acute therapeutic approach for symptomatic BPH.
To develop an effective treatment that avoids long-term androgen deprivation-induced side effects.

Main Methods:

Leveraging findings from seminal studies by Walsh and Coffey et al. regarding prostate stromal (S) and epithelial (E) compartment interactions.
Investigating the role of stem cell organization and reciprocal paracrine/autocrine signaling in the prostate.
Proposing a therapeutic strategy involving acute, reversible androgen deprivation followed by external beam radiation.

Main Results:

Androgen deprivation disrupts S-E interactions, decreasing prostate weight, but does not eliminate stem cell units.
Acute androgen deprivation sensitizes S-E interactions to radiation, preventing full gland regrowth upon androgen restoration.
This suggests an acute treatment model is viable.

Conclusions:

An effective acute therapy for symptomatic BPH can be achieved through a limited period of reversible androgen deprivation.
This is followed by a single dose of conformal external beam radiation.
Subsequent restoration of normal serum testosterone levels is anticipated.