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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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FEF75 in asthma management.

Di Berardino Luigi¹, Della Torre Emanuel, Di Berardino Federica

¹Paediatric Allergist, G.P. ASL Milan, Italy.

European Annals of Allergy and Clinical Immunology

|April 5, 2008

Summary

This summary is machine-generated.

Forced expiratory flow at 75% (FEF75) is a useful marker for monitoring allergic asthma. This spirometry parameter showed greater reduction than FEV1 and PEF, even when FEV1 was normal, indicating its value in early bronchial impairment detection.

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Area of Science:

Pulmonary Medicine
Respiratory Physiology
Allergology

Background:

Asthma diagnosis relies on symptoms and lung function tests like FEV1 and PEF.
FEF75 may indicate early bronchial impairment in allergic rhinitis patients.

Purpose of the Study:

To determine the most reliable spirometric parameter for tracking intermittent allergic asthma.

Main Methods:

Retrospective analysis of 108 intermittent allergic asthma outpatients.
Spirometry (FEV1, PEF, FEF75) assessed before and after 1 week of aerosol therapy.
Patients grouped by baseline FEV1 and FEF75 values.

Main Results:

FEF75 showed a more significant reduction than FEV1 and PEF.
68% of patients with normal FEV1 had reduced FEF75.
FEV1 improved post-therapy, but FEF75 often remained reduced, decreasing correlation.

Conclusions:

FEF75 warrants consideration as a valuable spirometric tool for monitoring allergic asthma.
FEF75 may detect bronchial impairment missed by FEV1 and PEF.