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Risk factors for cervical cancer in China: a case-control study
1Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, P.R. China. chb2105@sohu.com
Objectives:
To determine the prevalence of human papillomavirus types and investigate the risk factors for cervical cancer in Hubei, China.
Methods:
We conducted a case-control study to investigate risk factors.
Results:
HPV DNA was detected in 94.55% of patients with cervical carcinoma, and 23.64% of control subjects. The most common HPV type in cervical cancer was HPV type 16 (81.82%), followed by HPV 58 (6.36%). HPV infected patients have a higher risk of developing cervical carcinoma, which is 75.79 times more than non-infected people. The other risks were age at first intercourse (p = 0.017) and number of live births (p = 0.032). A history of previous cytologic screening was associated with a substantial reduction in risk (p = 0.001).
Conclusions:
The three principal reasons that Hubei has a high rate of women developing cervical carcinoma are HPV infection, age at first sexual intercourse and number of live births. Cervical cytology screening provides efficacious protection.
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