Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Mast-cell rosettes in the immunized rat].

M L Renoux, D Wallach

    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vintage descriptions of IgA pemphigus.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2022
    Same author

    A relapsing localized variant of neutrophilic dermatosis triggered by tissue injury.

    The British journal of dermatology·2020
    Same author

    Age-specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019
    Same author

    Atopic Dermatitis, The Skin-Disease.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2017
    Same author

    Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses.

    The British journal of dermatology·2015
    Same author

    Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.

    Cell death and differentiation·2015
    Same journal

    [Saltatory propagation of the nerve impulse in the Akiyama nerve].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Nycthemeral variations of the urinary excretion of acid mucopolysaccharides and of the blood levels of seromucoids. Influence of a hypophysial or adrenal factor].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Statistical distribution of the ABO blood groups in the population of the Bas-Rhin, and comparison with those of adjacent departments].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Method of measuring the variations in peripheral vascular capacity by the use of human serum albumin labeled with I-131].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Action of nialamide on coronary circulation. The influence exerted by a serotonin antagonist on the action of nialamide and of iproniazid].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Pharmacodynamics of the human round ligament. Action of acetylcholine, esterine, adrenaline and oxytocin].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    See all related articles

    Rat mast cells form rosettes with antigen-coated red blood cells after stimulation. This rosette formation, linked to anaphylactic antibodies, is inhibited by prior antigen exposure, offering insights into immune responses.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Rat peritoneal mast cells play a key role in allergic and inflammatory responses.
    • Anaphylactic antibodies are crucial mediators in mast cell activation.

    Purpose of the Study:

    • To investigate the phenomenon of mast cell rosette formation with antigen-coated erythrocytes.
    • To explore the role of membrane-bound anaphylactic antibodies in this process.
    • To correlate mast cell rosette formation with P.C.A. titers during immunization.

    Main Methods:

    • Mast cells were stimulated with ovalbumin + Bordetella pertussis.
    • Rosette formation assay with antigen-coated erythrocytes was performed.
    • Inhibition of rosette formation by pre-incubation with antigen was assessed.
    • Percentage of rosette-forming mast cells was monitored throughout immunization and compared to P.C.A. titers.

    Related Experiment Videos

    Main Results:

    • Rat peritoneal mast cells formed rosettes with antigen-coated erythrocytes post-stimulation.
    • Pre-incubation of mast cells with antigen inhibited rosette formation.
    • This inhibition is attributed to the appearance of membrane-bound anaphylactic antibodies.
    • Variations in rosette-forming mast cells correlated with P.C.A. titers during immunization.

    Conclusions:

    • Mast cell rosette formation is a measurable indicator of anaphylactic antibody presence.
    • The study elucidates a mechanism involving membrane-bound antibodies in mast cell-erythrocyte interactions.
    • This phenomenon provides a model for studying mast cell-mediated immune responses and antibody dynamics.