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Perinatal factors associated with the neurologic impairment of children born preterm

Snjezana Skrablin1, Ivana Maurac, Vladimir Banović

  • 1Department of Perinatal Medicine, School of Medicine, University of Zagreb, Croatia. vladimir.banovic2@zg.htnet.hr

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|April 5, 2008
PubMed

Insights

Perinatal infection, asphyxia, and abnormal brain ultrasound findings are key risk factors for long-term neurologic impairment in preterm infants. Primigravidity is linked to minimal cerebral dysfunction.

Area of Science:

  • Neonatal neurology
  • Perinatal medicine
  • Developmental pediatrics

Background:

  • Preterm infants face increased risks of long-term neurologic impairment.
  • Identifying specific perinatal risk factors is crucial for early intervention and improved outcomes.

Purpose of the Study:

  • To investigate perinatal risk factors associated with long-term neurologic impairment in preterm infants.
  • To differentiate risk factors for cerebral palsy and minimal cerebral dysfunction.

Main Methods:

  • A case-control study design was employed.
  • Included 60 neurologically impaired and 60 healthy preterm infants.
  • Analyzed various perinatal and maternal factors.

Main Results:

  • Cerebral palsy correlated with early neurologic signs, perinatal asphyxia, neonatal septicemia, abnormal brain ultrasound, prolonged membrane rupture-delivery interval, and placental lesions.
  • Minimal cerebral dysfunction was more frequent in first-born infants.
  • Perinatal infection, asphyxia, abnormal brain ultrasound, and placental lesions were independent predictors of impairment.

Conclusions:

  • Perinatal infection, perinatal asphyxia, and abnormal brain ultrasound findings are significant risk factors for cerebral palsy.
  • Primigravidity is associated with minimal cerebral dysfunction.
  • These findings aid in identifying high-risk preterm infants.
Abstract

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