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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Hyperglycemia and cognitive outcome after ischemic stroke.
N D Kruyt1, G M S Nys, H B van der Worp
1Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands. N.D.Kruijt@amc.uva.nl
Journal of the Neurological Sciences
|April 5, 2008
Summary
Post-stroke hyperglycemia (HG) was not linked to long-term cognitive decline in ischemic stroke patients. However, acute HG correlated with executive dysfunction in those with cortical infarcts.
Area of Science:
- Neurology
- Endocrinology
Background:
- Post-stroke hyperglycemia (HG) is linked to poor physical recovery, especially in cortical stroke patients.
- The association between HG and cognitive impairment after ischemic stroke requires further investigation.
Purpose of the Study:
- To determine if hyperglycemia is associated with cognitive impairment after ischemic stroke.
- To explore the relationship between HG, cognitive function, and stroke characteristics.
Main Methods:
- Prospective cohort study of patients with first-ever supratentorial infarct.
- Neuropsychological testing assessed various cognitive domains.
- HG (glucose >7.0 mmol/L) was related to cognitive outcomes, functional status, neurological deficit, and infarct size.
Main Results:
- In the acute phase, HG in cortical infarct patients was linked to impaired executive function, larger lesion size, and severe neurological deficits.
- These associations were not found in subcortical infarct patients.
- No significant association between HG and cognitive function was observed at 6-10 months follow-up.
Conclusions:
- Hyperglycemia is not associated with long-term cognitive impairment after ischemic stroke.
- Acute hyperglycemia is associated with executive dysfunction specifically in patients with cortical infarcts.
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